Aim: To investigate if overweight and obesity were associated with a higher degree of biochemical recurrence (BCR) after radical prostatectomy, in Mexican men with prostate cancer (PCa).Methods: We included 180 men with PCa, who underwent radical prostatectomy (RP). Body mass index (BMI) was determined and the degree of PCa aggressiveness was established according to the D'Amico classification. Postoperative follow-up of all patients was performed with PSA quantification every/6 weeks after surgery and then at 3-month intervals for 1 year, followed every/6 months for 5 years. Postoperative BCR was defined as two consecutive increases in PSA levels ≥0.4 ng/mL, after RP.Results: Sixty eight percent of the patients presented overweight or obesity. We found that only intermediate/high risk patients presented an increased risk factor for BCR-free survival (HR = 4.39; 95% CI = 1.74-11.24; p = 0.002). The median follow-up of all men has been 7.9 years and no significant differences in BCR-free survival time has been observed between the BMI groups.Conclusions: The overweight and obesity do not represent a risk factor to present BCR after RP for PCa. However, an intermediate/high risk, according to the D'Amico's classification, constitutes a risk factor to present BCR after radical prostatectomy, which is not related to the BMI.

中文翻译：

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前列腺癌患者的超重和肥胖并不构成生化复发的危险因素。

目的：调查墨西哥男性前列腺癌 (PCa) 患者的超重和肥胖是否与根治性前列腺切除术后较高程度的生化复发 (BCR) 相关。方法：我们纳入了 180 名接受根治性前列腺切除术 (RP) 的 PCa 男性. 根据 D'Amico 分类确定体重指数 (BMI) 并确定 PCa 侵袭性程度。术后每 6 周对所有患者进行 PSA 定量随访，然后每隔 3 个月进行 1 年随访，然后每 6 个月随访 5 年。术后 BCR 定义为 RP 后 PSA 水平连续两次升高≥0.4 ng/mL。结果：68% 的患者出现超重或肥胖。我们发现只有中/高风险患者的无 BCR 生存风险因素增加（HR = 4.39；95% CI = 1.74-11.24；p = 0.002）。所有男性的中位随访时间为 7.9 年，未观察到 BMI 组之间无 BCR 生存时间的显着差异。结论：超重和肥胖不代表 PCa RP 后出现 BCR 的危险因素。然而，根据 D'Amico 的分类，中/高风险构成根治性前列腺切除术后出现 BCR 的风险因素，这与 BMI 无关。超重和肥胖并不代表 PCa RP 后出现 BCR 的风险因素。然而，根据 D'Amico 的分类，中/高风险构成根治性前列腺切除术后出现 BCR 的风险因素，这与 BMI 无关。超重和肥胖并不代表 PCa RP 后出现 BCR 的风险因素。然而，根据 D'Amico 的分类，中/高风险构成根治性前列腺切除术后出现 BCR 的风险因素，这与 BMI 无关。