Abstract

A chemical investigation of Sophora flavescens Ait. identified 6 compounds. On the basis of spectroscopic data, they were determined to be flavonoids and their analogues, among which were two previously undescribed compounds, sophoflavanone G (1) and sophoflavanone H (2). The inhibitory effects of new compounds against five human tumour cell lines were evaluated in vitro by MTT assays, which revealed potential inhibitory effects with IC₅₀ values < 20 mM, in particular, compound 1 has shown significant cytotoxicity for several tumour cells with IC₅₀ values around 20 mM, which was similar to cisplatin and potential to be used as tumour drugs.

摘要

苦参的化学研究。鉴定了 6 种化合物。根据光谱数据，它们被确定为黄酮类化合物及其类似物，其中有两种先前未描述的化合物，即槐花酮G（1）和槐花黄酮H（2）。新化合物对五种人肿瘤细胞系的抑制作用在体外通过 MTT 测定法进行了评估，结果显示潜在的抑制作用，IC ₅₀值 < 20 mM，特别是化合物1对几种具有 IC ₅₀值的肿瘤细胞显示出显着的细胞毒性约 20 mM，与顺铂相似，可用作肿瘤药物。