ABSTRACT

Background: Endometriosis does not have a well-established physiopathology. It has been addressed that endometriosis is an inflammatory disease, where endocrine-immunological interactions are probably involved in the pathogenesis of the disease. The role of the immune system in endometriosis has been suggested to play an important role in both initiation and progression of the disease.

Methods: A search for the following keywords was performed in the PubMed database: “endometriosis”, “endometriosis and ovarian cancer”, “endometriosis and immunology”, and “endometriosis and cytokines”.

Results: The articles identified were published in English between 1921 and 2020. We selected 100 articles for further analysis.

Conclusion: The recognition of the direct involvement of these two important physiological mechanisms causes a change in the pathophysiological focus of the disease. Researching the activities of numerous cells involved in immune reactions may offer new therapeutic targets.

摘要

背景：子宫内膜异位症没有完善的病理生理学。已经解决了子宫内膜异位症是一种炎症性疾病，其中内分泌 - 免疫学相互作用可能参与该疾病的发病机制。免疫系统在子宫内膜异位症中的作用被认为在疾病的发生和发展中都起着重要作用。

方法：在 PubMed 数据库中搜索以下关键词：“子宫内膜异位症”、“子宫内膜异位症和卵巢癌”、“子宫内膜异位症和免疫学”和“子宫内膜异位症和细胞因子”。

结果：确定的文章发表于 1921 年至 2020 年之间的英文版本。我们选择了 100 篇文章进行进一步分析。

结论：认识到这两种重要生理机制的直接参与导致疾病病理生理学焦点的改变。研究参与免疫反应的众多细胞的活动可能会提供新的治疗靶点。