Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in Candida albicans and Candida auris,Biofouling

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Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in Candida albicans and Candida auris
Biofouling ( IF 2.6 ) Pub Date : 2020-03-15 , DOI: 10.1080/08927014.2020.1759559
Juanjuan Liu ₁ , Qianqian Li ₁ , Changzhong Wang _{1,

2,

3,

4} , Jing Shao _{1,

2,

3,

4} , Tianming Wang _{1,

3,

4} , Daqiang Wu _{1,

2,

3,

4} , Kelong Ma _{1,

2,

3,

4} , Guiming Yan _{1,

3,

4} , Dengke Yin _{4,

5,

6}

Affiliation

Abstract Traditional herbal monomers (THMs) are widely distributed in many traditional Chinese formulas (TCFs) and decoctions (TCDs) and are frequently used for the prevention and treatment of fungal infections. The antifungal activities of five common THMs, including sodium houttuyfonate (SH), berberine (BER), palmatine (PAL), jatrorrhizine (JAT) and cinnamaldehyde (CIN), and their potential for inducing cell wall remodeling (CWR), were evaluated against Candida albicans SC5314 and Candida auris 12372. SH/CIN plus BER/PAL/JAT showed synergistic antifungal activity against both Candida isolates. Furthermore, SH-associated combinations (SH plus BER/PAL/JAT) induced stronger exposure of β-glucan and chitin than their counterparts, while CIN triggered more marked exposure compared with CIN-associated combinations (CIN plus BER/PAL/JAT). Collectively, this study demonstrated the anti-Candida effect and the CWR induction potential of the five THMs and their associated combinations, providing a possibility of their in vivo application against fungal-associated infections.

中文翻译：

传统草药单体的抗真菌评估及其诱导白色念珠菌和耳念珠菌细胞壁重塑的潜力

摘要传统草药单体（THMs）广泛分布于多种中药方剂（TCFs）和汤剂（TCDs）中，常用于预防和治疗真菌感染。五种常见 THMs 的抗真菌活性，包括鱼腥草酸钠 (SH)、小檗碱 (BER)、巴马汀 (PAL)、药根碱 (JAT) 和肉桂醛 (CIN)，以及它们诱导细胞壁重塑 (CWR) 的潜力。白色念珠菌 SC5314 和耳念珠菌 12372。SH/CIN 加 BER/PAL/JAT 显示出对两种念珠菌分离株的协同抗真菌活性。此外，SH 相关组合（SH 加 BER/PAL/JAT）比其对应物诱导更强的 β-葡聚糖和几丁质暴露，而与 CIN 相关组合（CIN 加 BER/PAL/JAT）相比，CIN 引发更显着的暴露。总的来说，

更新日期：2020-03-15

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