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Comparison Analysis between the Medication Efficacy of the Milnacipran and Functional Connectivity of Neural Networks in Fibromyalgia Patients.
Brain Sciences ( IF 2.7 ) Pub Date : 2020-05-15 , DOI: 10.3390/brainsci10050295
Seong-Ho Kim 1 , Min-Woo Lee 2, 3 , Min-Jae Kang 2, 4 , Sung Gun Lee 1 , Jung-Goo Lee 5, 6, 7 , Chi-Woong Mun 2
Affiliation  

Milnacipran is a reuptake inhibitor of both serotonin and noradrenaline, used in the treatment of fibromyalgia with severe depression. However, few studies have been conducted on the efficacies of milnacipran drug on the functional connectivity of the neural network. The authors aimed to find the correlation between the drug efficacy and the changes in neural network in fibromyalgia patients. Resting-state-functional magnetic resonance imaging (rs-fMRI) were obtained before and after milnacipran drug administration. Graph theory indexes and small-worldness were calculated using preprocessed blood-oxygen-level-dependent signals from the rs-fMRI scans of 14 brain regions-of-interest. Statistical analyses were conducted to compare the topological network parameters. Significant changes in the neural network indexes appeared in three of the 14 brain regions-of-interest. In the pain network, the average path length on the left side of Brodmann area 32 was shortened. In the default mode network, functional connectivity changes were observed in the left lateral parietal cortex and medial prefrontal cortex. In the left lateral parietal cortex, the degree and betweenness centrality increased, whereas the clustering coefficient decreased. In the medial prefrontal cortex, local efficiency decreased. The small-worldness declined after milnacipran medication. The present results demonstrate that functional connectivity indexes in the brains of female fibromyalgia patients obtained from rs-fMRI data can be used as potential prognosis markers of milnacipran drug treatment.

中文翻译:

Milnacipran的药物治疗效果与纤维肌痛患者神经网络的功能连通性的比较分析。

Milnacipran是5-羟色胺和去甲肾上腺素的再摄取抑制剂,用于治疗重度抑郁的纤维肌痛。但是,关于米那普仑药物对神经网络功能连通性的功效的研究很少。作者旨在寻找纤维肌痛患者的药物疗效与神经网络变化之间的相关性。在米那普仑给药之前和之后均获得了静止状态功能磁共振成像(rs-fMRI)。使用来自14个大脑感兴趣区域的rs-fMRI扫描的预处理血氧水平相关信号,计算了图论指数和小世界。进行统计分析以比较拓扑网络参数。在14个大脑感兴趣区域中的三个中,神经网络指数出现了显着变化。在疼痛网络中,Brodmann区域32左侧的平均路径长度缩短了。在默认模式网络中,在左侧顶叶皮层和内侧前额叶皮层中观察到功能连接性变化。在左侧顶叶皮层中,中间度和中间度增加,而聚集系数降低。在内侧前额叶皮层,局部效率下降。米那普仑用药后小世界减少了。目前的结果表明,从rs-fMRI数据获得的女性纤维肌痛患者大脑中的功能连通性指数可以用作米那普仑药物治疗的潜在预后指标。布罗德曼区域32左侧的平均路径长度缩短了。在默认模式网络中,在左侧顶叶皮层和内侧前额叶皮层中观察到功能连接性变化。在左侧顶叶皮层中,中间度和中间度增加,而聚集系数降低。在内侧前额叶皮层,局部效率下降。米那普仑用药后小世界减少了。目前的结果表明,从rs-fMRI数据获得的女性纤维肌痛患者大脑中的功能连通性指数可以用作米那普仑药物治疗的潜在预后指标。布罗德曼区域32左侧的平均路径长度缩短了。在默认模式网络中,在左侧顶叶皮层和内侧前额叶皮层中观察到功能连接性变化。在左侧顶叶皮层中,中间度和中间度增加,而聚集系数降低。在内侧前额叶皮层,局部效率下降。米那普仑用药后小世界减少了。目前的结果表明,从rs-fMRI数据获得的女性纤维肌痛患者大脑中的功能连通性指数可以用作米那普仑药物治疗的潜在预后指标。左侧外侧顶叶皮层和内侧前额叶皮层中观察到功能连接性变化。在左侧顶叶皮层中,中间度和中间度增加,而聚集系数降低。在内侧前额叶皮层,局部效率下降。米那普仑用药后小世界减少了。目前的结果表明,从rs-fMRI数据获得的女性纤维肌痛患者大脑中的功能连通性指数可以用作米那普仑药物治疗的潜在预后指标。在左侧顶叶皮层和内侧前额叶皮层中观察到功能连接性变化。在左侧顶叶皮层中,中间度和中间度增加,而聚集系数降低。在内侧前额叶皮层,局部效率下降。米那普仑用药后小世界减少了。目前的结果表明,从rs-fMRI数据获得的女性纤维肌痛患者大脑中的功能连通性指数可以用作米那普仑药物治疗的潜在预后指标。米那普仑用药后小世界减少了。目前的结果表明,从rs-fMRI数据获得的女性纤维肌痛患者大脑中的功能连通性指数可以用作米那普仑药物治疗的潜在预后指标。米那普仑用药后小世界减少了。目前的结果表明,从rs-fMRI数据获得的女性纤维肌痛患者大脑中的功能连通性指数可以用作米那普仑药物治疗的潜在预后指标。
更新日期:2020-05-15
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