Resveratrol (RSV) is a bioactive natural molecule that induces antioxidant activity and increases protection against oxidative damage. RSV could be used to mitigate damages associated to metabolic diseases and aging. Particularly, RSV regulates different aspects of mitochondrial metabolism. However, no information is available about the effects of RSV on Coenzyme Q (CoQ), a central component in the mitochondrial electron transport chain. Here, we report for the first time that RSV modulates COQ genes and parameters associated to metabolic syndrome in mice. Mice fed with high fat diet (HFD) presented a higher weight gain, triglycerides (TGs) and cholesterol levels while RSV reverted TGs to control level but not weight or cholesterol. HFD induced a decrease of COQs gene mRNA level, whereas RSV reversed this decrease in most of the COQs genes. However, RSV did not show effect on CoQ9, CoQ10 and total CoQ levels, neither in CoQ-dependent antioxidant enzymes. HFD influenced mitochondrial dynamics and mitophagy markers. RSV modulated the levels of PINK1 and PARKIN and their ratio, indicating modulation of mitophagy. In summary, we report that RSV influences some of the metabolic adaptations of HFD affecting mitochondrial physiology while also regulates COQs gene expression levels in a process that can be associated with mitochondrial dynamics and turnover.

中文翻译：

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白藜芦醇调节高脂饮食喂养的小鼠肝脏中参与辅酶Q合成的基因的表达。

白藜芦醇（RSV）是具有生物活性的天然分子，可诱导抗氧化活性并增强抵抗氧化损伤的保护作用。RSV可用于减轻与代谢疾病和衰老相关的损害。特别是，RSV调节线粒体代谢的不同方面。但是，目前尚无有关RSV对辅酶Q（CoQ）的影响的信息，辅酶Q（CoQ）是线粒体电子传输链的重要组成部分。在这里，我们第一次报告RSV调节小鼠代谢综合征相关的COQ基因和参数。饲喂高脂饮食（HFD）的小鼠体重增加，甘油三酸酯（TGs）和胆固醇水平更高，而RSV将TGs恢复至控制水平，但体重或胆固醇却没有升高。HFD导致COQs基因mRNA水平降低，而RSV逆转了大多数COQs基因的这种降低。但是，RSV并未显示对辅酶Q9，辅酶Q10和总辅酶Q的影响，在辅酶Q依赖性抗氧化剂中也没有。HFD影响线粒体动力学和线粒体标记。RSV调节了PINK1和PARKIN的水平及其比例，表明对线粒体的调节。总而言之，我们报道RSV影响了影响线粒体生理的HFD的某些代谢适应性，同时还调节了与线粒体动力学和更新相关的过程中的COQs基因表达水平。