Antibacterial activity of Barbatimão ( Stryphnodendron adstringens ) against Staphylococcus aureus : in vitro and in silico studies.,Letters in Applied Microbiology

当前位置： X-MOL 学术 › Lett. Appl. Microbiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Antibacterial activity of Barbatimão ( Stryphnodendron adstringens ) against Staphylococcus aureus : in vitro and in silico studies.
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-06-04 , DOI: 10.1111/lam.13317
D A C Trevisan ₁ , P V da Silva ₂ , A B P Farias ₁ , P A Z Campanerut-Sá ₁ , T D V R Ribeiro ₃ , D R Faria ₁ , P S B de Mendonça ₁ , J C P de Mello ₃ , F A V Seixas ₂ , J M G Mikcha ₁

Affiliation

We evaluated the activity of the aqueous fraction and the ethyl acetate fraction of Stryphnodendron adstringens against Staphylococcus aureus and proposed their mechanism of action. The antibacterial activity of S. adstringens fractions was evaluated against S. aureus and the cell targets were rated by docking. The fractions showed moderate antibacterial activity against S. aureus without toxicity on two mammalian cell lines. They also showed synergistic antibacterial activity with tannic acid. In silico assays indicated FabG, FabZ, and FabI as probable targets. The metabolic pathway for fatty acid biosynthesis in S. aureus was affected by components of S. adstringens. The synergistic effect when combining tannic acid with S.adstringens fractions suggests a natural alternative to S. aureus control.

中文翻译：

Barbatimão ( Stryphnodendron adstringens ) 对金黄色葡萄球菌的抗菌活性：体外和计算机研究。

我们评估了 Stryphnodendron adstringens 的水部分和乙酸乙酯部分对金黄色葡萄球菌的活性，并提出了它们的作用机制。针对 S. aureus 评估了 S. adstringens 组分的抗菌活性，并通过对接对细胞靶标进行了评级。这些馏分对金黄色葡萄球菌表现出中等的抗菌活性，对两种哺乳动物细胞系没有毒性。它们还显示出与单宁酸的协同抗菌活性。计算机分析表明 FabG、FabZ 和 FabI 作为可能的靶标。S. aureus 中脂肪酸生物合成的代谢途径受 S. adstringens 成分的影响。将单宁酸与 S.adstringens 部分组合时的协同效应表明是金黄色葡萄球菌控制的天然替代品。

更新日期：2020-06-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11