Lesion–symptom mapping studies have reported a temporal versus frontal dissociation between semantic and letter fluency, and mixed evidence regarding the role of white matter. Mass‐univariate and multivariate lesion–symptom mapping was used to identify regions associated with semantic and letter fluency deficits in post‐stroke aphasia. Multivariate LSM revealed broad networks including underlying white matter, and substantial overlap between both types of fluency, suggesting that semantic fluency and letter fluency largely rely on the same neural system. All data are available on OSF.

中文翻译：

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中风后失语症中语义和字母流畅度的共同病灶相关性

病变-症状映射研究报告了语义和字母流畅性之间的时间与额叶分离，以及关于白质作用的混合证据。大量单变量和多变量病变-症状映射用于识别与中风后失语症中语义和字母流畅性缺陷相关的区域。多元 LSM 揭示了广泛的网络，包括潜在的白质，以及两种流畅性之间的大量重叠，表明语义流畅性和字母流畅性在很大程度上依赖于相同的神经系统。所有数据均可在 OSF 上获得。