Low level of antifungal resistance of Candida glabrata blood isolates in Turkey: fluconazole minimum inhibitory concentration and FKS mutations can predict therapeutic failure,Mycoses

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Low level of antifungal resistance of Candida glabrata blood isolates in Turkey: fluconazole minimum inhibitory concentration and FKS mutations can predict therapeutic failure
Mycoses ( IF 4.1 ) Pub Date : 2020-08-05 , DOI: 10.1111/myc.13104
Amir Arastehfar _{1,

2} , Farnaz Daneshnia ₁ , Mohammadreza Salehi ₃ , Melike Yaşar ₄ , Tuğrul Hoşbul ₅ , Macit Ilkit ₆ , Weihua Pan ₁ , Ferry Hagen _{2,

7,

8} , Nazlı Arslan ₉ , Hatice Türk-Dağı ₁₀ , Süleyha Hilmioğlu-Polat ₄ , David S Perlin ₁₁ , Cornelia Lass-Flörl ₁₂

Affiliation

Shanghai Key Laboratory Molecular Medical Mycology, Shanghai, China.
Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Microbiology, Faculty of Medicine, Ege University, Izmir, Turkey.
Department of Medical Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Division of Mycology, Faculty of Medicine, Çukurova University, Adana, Turkey.
University Medical Center Utrecht, Utrecht, The Netherlands.
People's Hospital, Jining, China.
Department of Medical Microbiology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
Department of Microbiology, Faculty of Medicine, Selcuk University, Konya, Turkey.
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.

Candida glabrata is the third leading cause of candidaemia in Turkey; however, the data regarding antifungal resistance mechanisms and genotypic diversity in association with their clinical implication are limited.

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