Betulinic acid induces apoptosis and impairs migration and invasion in a mouse model of ovarian cancer.,Journal of Food Biochemistry

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Betulinic acid induces apoptosis and impairs migration and invasion in a mouse model of ovarian cancer.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-05-15 , DOI: 10.1111/jfbc.13278
Lingyun Liao ₁ , Chi Liu ₂ , Xiaoying Xie ₁ , Jieli Zhou ₁

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Betulinic acid (BA) was verified to possess plenty of biological activities including anti‐tumor, anti‐inflammatory and so on. In our research, we studied the growth inhibition, apoptosis promotion and metastasis resistance of ovarian cancer cells by BA. The result showed that BA showed a time‐ and dose‐dependent inhibitory effect on ovarian cancer cell lines. SKOV3 cell line proliferation has a concentration‐ and time‐dependently, which may be inhibited by BA. Furthermore, BA inhibited the metastasis of tumor cells remarkably by inhibiting epithelial‐mesenchymal transition process. Beyond that, the weight and volume of subcutaneous tumor was distinctly suppressed by administration of BA in tumor‐bearing mice of SKOV3 cells. Pathological and immunohistochemical tests showed that Ki‐67⁺ and MMP‐2⁺ cells were dramatically decreased after BA administration, indicating that BA can not only suppress proliferation, but also inhibit migration of tumor cells. Taken together, BA can be a valuable candidate drug for the treatment of ovarian cancer.

中文翻译：

桦木酸在卵巢癌小鼠模型中诱导细胞凋亡并损害迁移和侵袭。

经验证，桦木酸（BA）具有大量的生物活性，包括抗肿瘤，抗炎等。在我们的研究中，我们通过BA研究了卵巢癌细胞的生长抑制，凋亡促进和抗转移性。结果表明，BA对卵巢癌细胞系具有时间和剂量依赖性的抑制作用。SKOV3细胞系增殖具有浓度和时间依赖性，可能被BA抑制。此外，BA通过抑制上皮-间质转化过程显着抑制了肿瘤细胞的转移。除此之外，在荷瘤小鼠SKOV3细胞中施用BA可明显抑制皮下肿瘤的重量和体积。病理和免疫组织化学测试显示Ki‐67 ⁺和MMP-2 ⁺施用BA后细胞显着减少，表明BA不仅可以抑制增殖，而且可以抑制肿瘤细胞的迁移。两者合计，BA可以是治疗卵巢癌的有价值的候选药物。

更新日期：2020-05-15

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