Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions,Journal of Food Biochemistry

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Toxicological and pharmacological assessment of a multiherbal phytopharmaceutical on Triton X‐1339‐induced hyperlipidemia and allied biochemical dysfunctions
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-05-14 , DOI: 10.1111/jfbc.13238
Afolabi C Akinmoladun ₁ , Adaugo Damilola Adegbamigbe ₁ , Nkechi Ruth Okafor ₁ , Sunday Solomon Josiah ₁ , M Tolulope Olaleye ₁

Affiliation

This study investigated the safety and therapeutic effect of a multiherbal tea (MHT) on Triton X‐1339‐induced hyperlipidemia and associated biochemical and tissue dysfunctions. An infusion of the MHT was assessed for phytoconstituents, proximate and mineral composition, and antioxidant activity. Wistar rats administered 200 mg/kg Triton X‐1399 were post‐treated with MHT for 14 days followed by biochemical estimations in serum, heart, liver, and kidney of animals. Hematological and histopathological evaluations of the blood, and liver, respectively, were also performed. Different phytochemicals were detected in MHT, toxic metals were absent and antioxidant activity was appreciable. Disturbances in glucose level and redox homeostasis, alterations in liver, kidney, and heart function markers, and imbalances in hematological parameters precipitated by triton toxicity were mitigated by posttreatment with MHT. Multiherbal tea also ameliorated triton‐induced hepatic histoarchitectural abnormalities. These results suggest that MHT is apparently an effective antilipemic tea with minimal or no side effects.

中文翻译：

多种植物药对Triton X-1339引起的高脂血症和相关生化功能障碍的毒理学和药理学评估

这项研究调查了多草茶（MHT）对Triton X-1339引起的高脂血症以及相关的生化和组织功能障碍的安全性和治疗作用。评估了MHT的注入液中的植物成分，邻近和矿物质组成以及抗氧化活性。将给予200 mg / kg Triton X-1399的Wistar大鼠用MHT后处理14天，然后对动物的血清，心脏，肝脏和肾脏进行生化评估。还分别进行了血液和肝脏的血液学和组织病理学评估。在MHT中检测到不同的植物化学物质，不存在有毒金属并且抗氧化活性显着。葡萄糖水平和氧化还原稳态的紊乱，肝，肾和心脏功能标志物的改变，MHT的后处理可减轻Triton毒性引起的血液学参数失衡。多草药茶还改善了tri病毒引起的肝组织结构异常。这些结果表明，MHT显然是一种有效的抗血脂茶，几乎没有副作用。

更新日期：2020-05-14

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