Circular RNAs (circRNAs) function as an essential regulator in the progression of oral squamous cell carcinoma (OSCC). However, the potential roles and mechanism of circRNAs in OSCC are still elusive. Here, this research investigates the roles and molecular mechanism of novel circRNA (circMDM2) in OSCC progression. Clinically, circMDM2 was overexpressed in OSCC tissue and cells, and the overexpression served as a poor prognostic factor for OSCC patients. Functionally, cellular experiments confirmed that circMDM2 accelerated OSCC cell proliferation and glycolysis in vitro and circMDM2 knockdown repressed the tumour growth in vivo. Mechanistically, circMDM2 sponged miR‐532‐3p to promote the hexokinase 2 (HK2), forming the circMDM2/miR‐532‐3p/HK2 axis. In conclusion, these findings demonstrated that circMDM2/miR‐532‐3p/HK2 axis promotes the proliferation and glycolysis of OSCC, rendering a potential diagnostic biomarker and prospective therapeutic target for OSCC.

中文翻译：

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环状RNA circMDM2通过靶向miR-532-3p / HK2促进口腔鳞状细胞癌的糖酵解。

环状RNA（circRNA）在口腔鳞状细胞癌（OSCC）的进程中起着至关重要的调节作用。但是，circRNA在OSCC中的潜在作用和机制仍不清楚。在这里，这项研究调查了新型circRNA（circMDM2）在OSCC进展中的作用和分子机制。临床上，circMDM2在OSCC组织和细胞中过表达，而过表达是OSCC患者不良的预后因素。从功能上讲，细胞实验证实circMDM2在体外可促进OSCC细胞增殖和糖酵解，而circMDM2抑制可抑制体内肿瘤的生长。从机理上讲，circMDM2用海绵擦拭miR‐532‐3p以促进己糖激酶2（HK2），形成circMDM2 / miR‐532‐3p / HK2轴。结论，