The aim of this research was to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by MnO₂ for bone tissue engineering applications. HA and MnO₂ were developed using sol‐gel and precipitation methods, respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microcopy (SEM), energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/MnO₂ scaffolds possess higher compressive strength, toughness, hardness, and density when compared to the pure HA scaffolds. After immersing the scaffold in the SBF solution, more deposited apatite appeared on the HA/MnO₂, which results in the rougher surface on this scaffold compared to the pure HA scaffold. Finally, the in vitro biological analysis using human osteoblast cells reveals that scaffolds are biocompatible with adequate ALP activity.

中文翻译：

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骨组织工程应用羟基磷灰石/二氧化锰纳米复合支架的力学和生物相容性评估

这项研究的目的是评估由纯羟基磷灰石（HA）制成并由MnO ₂改性的HA用于骨组织工程应用的支架的力学性能，生物相容性和降解行为。HA和MnO ₂分别使用溶胶-凝胶法和沉淀法开发。使用X射线衍射（XRD），傅立叶变换光谱（FTIR），扫描电子显微镜（SEM），能量色散光谱（EDS）和透射电子显微镜（TEM）表征支架的特性。使用体外细胞增殖和碱性磷酸酶（ALP）分析评估支架与细胞的相互作用。所得结果表明HA / MnO ₂与纯HA支架相比，该支架具有更高的抗压强度，韧性，硬度和密度。将支架浸入SBF溶液后，更多的沉积磷灰石出现在HA / MnO _2上，与纯HA支架相比，该支架的表面更粗糙。最后，使用人成骨细胞进行的体外生物学分析表明，支架具有足够的ALP活性，具有生物相容性。