当前位置：
X-MOL 学术
›
Int. J. Numer. Method. Biomed. Eng.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Application of patient-specific simulation workflow for obstructive sleep apnea diagnosis and treatment with a mandibular advancement device.
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-06-16 , DOI: 10.1002/cnm.3350 Alexander Pugachev 1 , Marleen Arnold 2 , Sebastian Burgmann 2 , Uwe Janoske 2 , Ákos Bicsák 3 , Dietmar Abel 3 , Johannes Linssen 3 , Lars Bonitz 3
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-06-16 , DOI: 10.1002/cnm.3350 Alexander Pugachev 1 , Marleen Arnold 2 , Sebastian Burgmann 2 , Uwe Janoske 2 , Ákos Bicsák 3 , Dietmar Abel 3 , Johannes Linssen 3 , Lars Bonitz 3
Affiliation
|
A computational fluid dynamics simulation workflow was developed to analyze the upper airway of patients with obstructive sleep apnea, which is a potentially serious sleep‐related breathing disorder. A single characteristic parameter was introduced to assess the severity of sleep apnea on the basis of the numerical results. Additionally, a fluid‐structure interaction simulation was applied to study in detail the behavior of compliant pharyngeal walls. An experimental setup was designed to validate the patient‐specific upper airway modeling. The suitability of the characteristic parameter was demonstrated in a retrospective analysis of radiological and clinical data of 58 patients as well as a prospective analysis of 22 patients. The simulation workflow was successfully used as part of an ongoing clinical investigation to predict the outcome of the obstructive sleep apnea treatment with a mandibular advancement device. The simulation results provided essential information about the critical region in the pharynx for the selection of an appropriate treatment and readily demonstrated the effect of mandibular protrusion on the air flow in the upper airway.
中文翻译：
使用下颌前移装置将患者特定的模拟工作流程应用于阻塞性睡眠呼吸暂停的诊断和治疗。
开发了计算流体动力学模拟工作流程来分析阻塞性睡眠呼吸暂停患者的上呼吸道，这是一种潜在的严重睡眠相关呼吸障碍。引入单一特征参数以根据数值结果评估睡眠呼吸暂停的严重程度。此外，还应用了流固耦合模拟来详细研究顺应性咽壁的行为。设计了一个实验装置来验证患者特定的上呼吸道模型。特征参数的适用性在对 58 名患者的放射学和临床数据的回顾性分析以及对 22 名患者的前瞻性分析中得到证实。模拟工作流程已成功用作正在进行的临床调查的一部分，以预测使用下颌前移装置治疗阻塞性睡眠呼吸暂停的结果。模拟结果为选择合适的治疗方法提供了有关咽部关键区域的基本信息，并轻松证明了下颌前突对上呼吸道气流的影响。
更新日期：2020-06-16
中文翻译：
使用下颌前移装置将患者特定的模拟工作流程应用于阻塞性睡眠呼吸暂停的诊断和治疗。
开发了计算流体动力学模拟工作流程来分析阻塞性睡眠呼吸暂停患者的上呼吸道，这是一种潜在的严重睡眠相关呼吸障碍。引入单一特征参数以根据数值结果评估睡眠呼吸暂停的严重程度。此外，还应用了流固耦合模拟来详细研究顺应性咽壁的行为。设计了一个实验装置来验证患者特定的上呼吸道模型。特征参数的适用性在对 58 名患者的放射学和临床数据的回顾性分析以及对 22 名患者的前瞻性分析中得到证实。模拟工作流程已成功用作正在进行的临床调查的一部分，以预测使用下颌前移装置治疗阻塞性睡眠呼吸暂停的结果。模拟结果为选择合适的治疗方法提供了有关咽部关键区域的基本信息，并轻松证明了下颌前突对上呼吸道气流的影响。
京公网安备 11010802027423号