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a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-06-04 , DOI: 10.1002/ejoc.202000503 Antal Harsanyi 1 , Anne Lückener 1 , Hedvig Pasztor 1 , Zahide Yilmaz 1 , Lawrence Tam 1 , Dmitry S. Yufit 1 , Graham Sandford 1
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-06-04 , DOI: 10.1002/ejoc.202000503 Antal Harsanyi 1 , Anne Lückener 1 , Hedvig Pasztor 1 , Zahide Yilmaz 1 , Lawrence Tam 1 , Dmitry S. Yufit 1 , Graham Sandford 1
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Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to the corresponding fluoro‐acetophenone, ‐1,3‐ketoester, ‐1,3‐diketone and ‐pyran‐4‐one products respectively from the same selectively fluorinated scaffold in one‐step procedures.
中文翻译：
α-氟代三羰基衍生物作为多功能氟化结构单元：氟代苯乙酮、氟代酮酯和氟代吡喃 4-one 衍生物的合成
氟化酰基-Meldrum 酸衍生物是通过使用 Selectfluor 对合适的苯甲酰基 Meldrum 酸底物进行亲电氟化来合成的。与水、乙醇、格氏试剂和炔基锂试剂的反应分别从同一选择性氟化支架中产生相应的氟苯乙酮、-1,3-酮酯、-1,3-二酮和-吡喃-4-one 产物-步骤程序。
更新日期：2020-06-04
中文翻译：
α-氟代三羰基衍生物作为多功能氟化结构单元：氟代苯乙酮、氟代酮酯和氟代吡喃 4-one 衍生物的合成
氟化酰基-Meldrum 酸衍生物是通过使用 Selectfluor 对合适的苯甲酰基 Meldrum 酸底物进行亲电氟化来合成的。与水、乙醇、格氏试剂和炔基锂试剂的反应分别从同一选择性氟化支架中产生相应的氟苯乙酮、-1,3-酮酯、-1,3-二酮和-吡喃-4-one 产物-步骤程序。
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