The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic-lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.

中文翻译：

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大脑的淋巴系统：当前的争议

近年来，随着脑膜淋巴管的发现，glymphatic 概念强调了液体在中枢神经系统 (CNS) 内定向运输。影像学研究以及液体转运的操作表明，glymphatic-lymphatic 系统在清除淀粉样蛋白 β 和其他蛋白质方面发挥着关键作用。因此，glymphatic-lymphatic 系统代表了对抗神经退行性疾病的新目标。不出所料，在大脑中引入新的管道系统引起了争议。这篇观点文章将重点介绍我们对大脑流体运输系统的了解、缺乏实验数据的内容以及仍有争议的内容。