Biochemical production faces economic and environmental challenges that need to be overcome to enable a viable and sustainable bioeconomy. We propose an assessment framework that consistently combines environmental and economic indicators to support optimized biochemical production at early development stages. We define internally consistent system boundaries and a comprehensive set of quantitative indicators from life cycle assessment (LCA) and techno-economic assessment (TEA) to combine environmental and economic performance in a single score. Our framework enables the identification of trade-offs across environmental and economic aspects over the entire biochemical life cycle. This approach provides input for the optimization of future biochemicals in terms of overall sustainability, to overcome prevailing obstacles in the development of biochemical production processes.

生化生产面临着经济和环境挑战，需要克服这些挑战才能实现可行和可持续的生物经济。我们提出了一个始终结合环境和经济指标的评估框架，以支持早期开发阶段的优化生化生产。我们定义了内部一致的系统边界和来自生命周期评估 (LCA) 和技术经济评估 (TEA) 的一套综合量化指标，将环境和经济绩效结合在一个单一的分数中。我们的框架能够在整个生化生命周期中确定环境和经济方面的权衡。这种方法为在整体可持续性方面优化未来的生化物质提供了投入，