Atypical cyclins have recently emerged as a new subfamily of cyclins characterized by common structural features and interactor pattern. Interestingly, atypical cyclins are phylogenetically close to canonical cyclins, which have well-established roles in cell cycle regulation and cancer. Therefore, although the function of atypical cyclins is still poorly characterized, it seems likely that they are involved in cancer pathogenesis as well. Here, we coupled gene expression and prognostic significance analysis to bibliographic search in order to provide new insights into the role of atypical cyclins in cancer. The information gathered suggests that atypical cyclins intervene in critical processes to sustain cancer growth and have potential to become novel prognostic markers and drug targets in cancer.

非典型细胞周期蛋白最近作为一个新的细胞周期蛋白亚家族出现，其特征是具有共同的结构特征和相互作用模式。有趣的是，非典型细胞周期蛋白在系统发育上接近经典细胞周期蛋白，后者在细胞周期调节和癌症中具有公认的作用。因此，尽管非典型细胞周期蛋白的功能仍不清楚，但它们似乎也与癌症发病机制有关。在这里，我们将基因表达和预后意义分析与书目搜索相结合，以提供对非典型细胞周期蛋白在癌症中的作用的新见解。收集到的信息表明，非典型细胞周期蛋白干预关键过程以维持癌症生长，并有可能成为癌症的新型预后标志物和药物靶点。