In modern drug delivery, seeking a drug delivery system (DDS) with a modifiable skeleton for proper targeting of loaded actives to specific sites in the body is of extreme importance for a successful therapy. Magnetically guided nanosystems, where particles such as iron oxides are guided to specific regions using an external magnetic field, can provide magnetic resonance imaging (MRI) while delivering a therapeutic payload at the same time, which represents a breakthrough in disease therapy and make MNPs excellent candidates for several biomedical applications. In this review, magnetic nanoparticles (MNPs) along with their distinguishable properties, including pharmacokinetics and toxicity, especially in cancer therapy will be discussed. The potential perspective of using other elements within the MNP system to reduce toxicity, improve pharmacokinetics, increase the magnetization ability, improve physical targeting precision and/or widen the scope of its biomedical application will be also discussed.

在现代药物输送中，寻求一种具有可修改骨架的药物输送系统（DDS），以将负载的活性物质正确地靶向体内的特定部位对于成功的治疗至关重要。磁性引导的纳米系统，其中使用外部磁场将诸如氧化铁之类的颗粒引导到特定区域，可以提供磁共振成像（MRI），同时提供治疗有效载荷，这代表了疾病治疗领域的突破，并使得MNP具有出色的性能几种生物医学应用的候选对象。在这篇综述中，将讨论磁性纳米粒子（MNP）及其可分辨的特性，包括药代动力学和毒性，尤其是在癌症治疗中。在MNP系统中使用其他元素降低毒性的潜在前景，