Maternal diabetes induces fetal programming of cardiovascular diseases. Diabetes induced-cardiac fibrosis is a process that may start in utero and may be related to the prooxidant/proinflammatory environment. The aim of this study was to investigate the effect of a maternal diet enriched in olive oil on the levels of components and regulators of the extracellular matrix, on prooxidant markers and on apoptosis rate in the heart of 21-day-old offspring of diabetic rats. Maternal diabetes was induced by neonatal administration of streptozotocin. During pregnancy, diabetic and control rats were fed with diets supplemented or not with 6% olive oil. The heart of the offspring was studied at 21 days of age. We found increased deposition of collagen IV and fibronectin in the offspring´s heart of diabetic rats, which was prevented by the maternal diets enriched in olive oil. Increases in connective tissue growth factor were also prevented by the maternal diets enriched in olive oil. Prooxidant markers as well as apoptosis, which were increased in the heart of the offspring of diabetic rats, were prevented by the maternal olive oil dietary treatment. Our findings identified powerful effects of a maternal diet enriched in olive oil on the prevention of increased extracellular matrix deposition and increased prooxidant markers in the heart of 21-day-old offspring of diabetic rats.

中文翻译：

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补充橄榄油可预防糖尿病大鼠后代心脏中细胞外基质的沉积，并减少促氧化剂标志物和细胞凋亡。

孕产妇糖尿病会诱发胎儿编程性心血管疾病。糖尿病诱发的心脏纤维化是可能在子宫内开始的过程，并且可能与促氧化剂/促炎环境有关。这项研究的目的是研究富含橄榄油的母体饮食对21天大的糖尿病大鼠后代心脏中细胞外基质的成分和调节剂水平，对促氧化剂标志物和细胞凋亡率的影响。 。新生儿服用链脲佐菌素可诱发母体糖尿病。在怀孕期间，对糖尿病和对照大鼠喂食补充或不补充6％橄榄油的饮食。在21天大的时候研究了后代的心脏。我们发现糖尿病大鼠后代心脏中的IV型胶原和纤连蛋白沉积增加，富含橄榄油的孕妇饮食可以预防这种情况。富含橄榄油的孕妇饮食也可以防止结缔组织生长因子的增加。母体橄榄油饮食治疗可预防糖尿病大鼠后代心脏中增加的促氧化剂标志物和细胞凋亡。我们的发现确定了富含橄榄油的孕妇饮食在预防21天大的糖尿病大鼠后代心脏中增加的细胞外基质沉积和增加的抗氧化剂标记方面的强大作用。被孕妇的橄榄油饮食治疗所预防。我们的发现确定了富含橄榄油的孕妇饮食在预防21天大的糖尿病大鼠后代心脏中增加的细胞外基质沉积和增加的抗氧化剂标记方面的强大作用。被孕妇的橄榄油饮食治疗所预防。我们的发现确定了富含橄榄油的孕妇饮食在预防21天大的糖尿病大鼠后代心脏中增加的细胞外基质沉积和增加的抗氧化剂标记方面的强大作用。