Research question

What are the potential differences between lean women with and without polycystic ovary syndrome (PCOS) in fat content in liver, vertebrae, paraspinal muscles, pancreas, subcutaneous (SCAT) and visceral adipose tissue (VAT)? Magnetic resonance imaging proton density fat fraction (PDFF) was used to establish these differences. This is a novel, non-invasive, operator-independent method with comparable diagnostic sensitivity and specificity to histologic examination for fatty liver disease, and strong correlation with muscle strength in neuromuscular studies.

Design

Twenty lean women with PCOS (mean age 23.9 ± 2.3; body mass index [BMI] 22.4 ± 2.0) and 20 age- and BMI-matched healthy women (mean age 24.9 ± 1.5; BMI 21.5 ± 1.9) were enrolled in this cross-sectional study. Anthropometric, biochemical and hormonal evaluations along with magnetic resonance imaging proton density fat fraction were carried out.

Results

PDFF% measurements of liver, SCAT and VAT were higher in the PCOS group, indicating increased fat content in these areas in lean women with PCOS compared with controls (P = 0.045, 0.030 and 0.037, respectively). In contrast, PDFF% values of vertebrae and paraspinal muscles in the PCOS group were lower than controls (P = 0.038 and 0.05, respectively). Pancreatic PDFF% measurements were similar between the groups. In the PCOS group, PDFF% of VAT was positively correlated with free androgen index (r = 0.69, P = 0.002).

Conclusions

PDFF% measurement, an MRI-based novel biomarker, reveals increased fat in liver, SCAT and VAT, and decreased fat in vertebral bones and paraspinal muscles of lean women with PCOS.

中文翻译：

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通过磁共振成像对组织脂肪进行定量：多囊卵巢综合征中的质子密度脂肪分数。

研究问题

有和没有多囊卵巢综合征（PCOS）的苗条女性在肝脏，椎骨，椎旁肌，胰腺，皮下（SCAT）和内脏脂肪组织（VAT）中的脂肪含量之间有何潜在差异？磁共振成像质子密度脂肪分数（PDFF）用于建立这些差异。这是一种新颖的，非侵入性的，独立于操作员的方法，具有与脂肪肝疾病的组织学检查相当的诊断敏感性和特异性，并且在神经肌肉研究中与肌肉力量具有很强的相关性。

设计

本研究纳入了20名PCOS瘦女性（平均年龄23.9±2.3；体重指数[BMI] 22.4±2.0）以及20名年龄和BMI匹配的健康女性（平均年龄24.9±1.5； BMI 21.5±1.9）。截面研究。进行了人体测量，生化和激素评估以及磁共振成像质子密度脂肪分数。

结果

在PCOS组中，肝脏，SCAT和VAT的PDFF％测量值较高，表明与对照组相比，患有PCOS的苗条女性在这些区域的脂肪含量增加（分别为P  = 0.045、0.030和0.037）。相反，PCOS组的椎骨和椎旁肌的PDFF％值低于对照组（ 分别为P = 0.038和0.05）。两组之间的胰腺PDFF％测量值相似。在PCOS组中，增值税的PDFF％与游离雄激素指数呈正相关（r = 0.69，P  = 0.002）。

结论

PDFF％测量是一种基于MRI的新型生物标志物，显示PCOS瘦女性的肝脏，SCAT和VAT中脂肪增加，椎骨和椎旁肌肉中脂肪减少。