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Carbazole alkaloids with bioactivities from the stems of Clausena lansium
Phytochemistry Letters ( IF 1.3 ) Pub Date : 2020-05-15 , DOI: 10.1016/j.phytol.2020.03.004
Xing-Yan Sun , Jie Ma , Chuang-Jun Li , Ying-Da Zang , Ji-Wu Huang , Xu-Yan Wang , Nai-Hong Chen , Xiao-Guang Chen , Dong-Ming Zhang

Four unreported carbazole alkaloids named as claulansines U – W (1, 2, 4), (–) -(2′R)-claulamine A (3b) and one known analogue, claulamine A (3a) were obtained from the stems of Clausena lansium. Their structures were demonstrated by spectroscopic experiments. The absolute configuration of claulansine U (1) was determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 protected PC12 cells against serum deprivation injury at 10μM — an increase of cell survival rates from 47.4 ± 4.3 % (model) to 67.8 ± 6.6 % and 63.3 ± 8.2 %, respectively. And compound 4 showed significant cytotoxicities to four human cancer cell lines, with IC50 values ranging from 2.16 to 4.94 μM.



中文翻译:

芥蓝茎中具有生物活性的咔唑生物碱

命名为claulansines四个未报告咔唑生物碱ù - W(124),( - ) - (2' - [R)-claulamine A(图3b)和一个已知的类似物,claulamine A(图3a获得)从茎黄皮黄皮。通过光谱实验证明了它们的结构。通过单晶X射线衍射分析确定了青草素U(1)的绝对构型。化合物12抗血清剥夺损伤保护PC12细胞在10 μM-细胞存活率分别从47.4±4.3%(模型)增加到67.8±6.6%和63.3±8.2%。和化合物4显示出细胞毒性显著至四个人癌细胞系,用IC 50个值范围为2.16至4.94 μ M.

更新日期:2020-05-15
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