In 2004, PINK1 was established as a gene linked to early onset of autosomal recessive juvenile Parkinsonism. Since then, tremendous efforts allowed involving the gene product in diverse events but with a strong focus on its partnership with the protein Parkin for the degradation of damaged mitochondria through mitophagy. Yet, it is now clear that the importance of PINK1 encompasses a wider spectrum of intracellular processes. In this minireview, we highlight some of the PINK1 interplays and recent advances, including its growing involvement in immunity and also its emerging place in this era of mitochondria-organelles contact sites.

中文翻译：

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PINK1 和 Parkin：奇怪的一对

2004 年，PINK1 被确定为与常染色体隐性青少年帕金森病早期发病相关的基因。从那时起，巨大的努力使得基因产物参与到不同的事件中，但重点关注它与蛋白质 Parkin 的合作，以通过线粒体自噬降解受损的线粒体。然而，现在很清楚 PINK1 的重要性包含更广泛的细胞内过程。在这篇小综述中，我们重点介绍了 PINK1 的一些相互作用和最新进展，包括它越来越多地参与免疫以及它在这个线粒体-细胞器接触位点时代的新兴地位。