TiO₂ particles are broadly used in daily products, including cosmetics for their UV-absorbing property, food for their white colouring property, water and air purification systems, self-cleaning surfaces and photoconversion electrical devices for their photocatalytic properties. The toxicity of TiO₂ nano- and microparticles has been studied for decades, and part of this investigation has been dedicated to the identification of their potential impact on DNA, i.e., their genotoxicity. This review summarizes data retrieved from their genotoxicity testing during the past 6 years, encompassing both in vitro and in vivo studies, mostly performed on lung and intestinal models. It shows that TiO₂ particles, both nano- and micro-sized, produce genotoxic damage to a variety of cell types, even at low, realistic doses.

TiO ₂颗粒因其吸收紫外线的特性而被广泛用于日用产品，包括具有吸收紫外线特性的化妆品、具有白色着色特性的食品、水和空气净化系统、自清洁表面和具有光催化特性的光转换电气设备。TiO ₂纳米粒子和微粒子的毒性已经研究了几十年，该研究的一部分致力于鉴定它们对DNA的潜在影响，即它们的遗传毒性。本综述总结了过去 6 年从他们的基因毒性测试中检索到的数据，包括体外和体内研究，主要在肺和肠道模型上进行。表明 TiO ₂ 纳米和微米大小的颗粒，即使在低的、现实的剂量下，也会对各种细胞类型产生基因毒性损伤。