To explore the influence of serum lactate dehydrogenase (LDH) level on remote diffusion-weighted imaging lesions (rDWILs) after spontaneous intracerebral hemorrhage (ICH). A consecutive cohort of 160 patients with spontaneous ICH who had brain MRI within 4 weeks of ICH onset were collected and analyzed retrospectively. rDWILs showed high signal on diffusion-weighted image (DWI) while low signal on apparent diffusion coefficient (ADC), and at least 20 mm away from the hemorrhage focus. The blood samples were obtained within 24 h after ICH onset from all patients. Lactate dehydrogenase (LDH) levels in blood were collected from serum biochemical tests. We use multivariate logistic regression analyses to investigate the association between serum LDH level and rDWILs after ICH. The average serum LDH level was 186.5 ± 35.6 U/L. And this level was higher in patients who presented rDWILs than in those without rDWILs. With the best cut-off value of 191 by using receiver operating characteristic (ROC) analysis, elevated LDH was associated with the presence of rDWILs independently (OR = 1.024, 95%CI = 1.011–1.037, P < 0.001) in the bivariate logistic regression analysis with adjustment for age, sex, previous ischemic stroke/TIA, smoker, SBP on admission, hematoma volume, and intraventricular hemorrhage (IVH). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of LDH ≥ 191 U/L for rDWILs were 70.4%, 72.2%, 33.9%, 94.2%, respectively. Our study suggests serum LDH level has a significant correlation with rDWILs after spontaneous ICH. Patients with higher serum LDH level in 24 h after ICH onset may be a useful predictor for rDWILs occurrence.

探讨血清乳酸脱氢酶（LDH）水平对自发性脑出血（ICH）后远距离弥散加权成像病变（rDWILs）的影响。连续收集160例自发性ICH患者，他们在ICH发病4周内进行了脑部MRI检查，并进行回顾性分析。rDWIL在扩散加权图像（DWI）上显示高信号，而在表观扩散系数（ADC）上显示低信号，并且距出血灶至少20 mm。在所有ICH患者发病后24小时内采集血样。从血清生化试验中收集血液中的乳酸脱氢酶（LDH）水平。我们使用多元logistic回归分析来调查ICH后血清LDH水平与rDWILs之间的关系。血清LDH的平均水平为186.5±35.6 U / L。出现rDWIL的患者的这一水平高于没有rDWIL的患者。通过接受者工作特征（ROC）分析得出的最佳截止值为191，在双变量logistic中，LDH升高与rDWIL的存在独立相关（OR = 1.024，95％CI = 1.011–1.037，P <0.001）年龄，性别，先前的缺血性卒中/ TIA，吸烟者，入院时的SBP，血肿量和脑室内出血（IVH）进行回归分析。LD≥191 U / L的rDWILs的敏感性，特异性，阳性预测值（PPV）和阴性预测值（NPV）分别为70.4％，72.2％，33.9％，94.2％。我们的研究表明，自发性ICH后血清LDH水平与rDWILs有显着相关性。