Abstract The need for a bone adhesive is a challenge that has remained unmet. The concept of a “bone glue” to repair simple and comminuted fractures, as well as to glue orthopaedic devices in place, is considered a holy grail. Today such a product has been developed to satisfy the properties necessary for a bone adhesive. Its simple chemistry, which is free of cytotoxic or mutagenic effects, reacts in a wet environment and is composed of a multi-phasic mineral-organic biomaterial that forms robust and durable bonds directly to living bone and metallic implants. Over the course of healing, the glue undergoes both evolution and dissolution, allowing bone substitution preserving both the strength of the glue and its volume. In clinical practice, the glue offers the possibility of providing immediate and extended stabilization, eliminating the need for high mechanical bone compression as in press fit or threaded implants and may negate the need for bone plating of fractures.

中文翻译：

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骨胶 - 骨折修复和植入式器械稳定的最后前沿

摘要 对骨粘合剂的需求是一个尚未得到满足的挑战。用于修复简单和粉碎性骨折以及将骨科设备粘合到位的“骨胶”概念被认为是圣杯。今天，已经开发出这样的产品以满足骨粘合剂所需的特性。其化学性质简单，无细胞毒性或致突变作用，可在潮湿环境中发生反应，由多相矿物有机生物材料组成，可直接与活体骨骼和金属植入物形成牢固而持久的结合。在愈合过程中，胶水会经历演变和溶解，从而允许骨骼替代，同时保持胶水的强度和体积。在临床实践中，胶水提供了提供即时和长期稳定的可能性，