This study was conducted to correlate clinical, laboratory, and bone marrow (BM) changes in cats naturally infected with feline leukemia virus and their association with viral loads in blood and BM and proviral loads in BM. Cats were classified into five groups based on antigenemia, clinical and/or laboratory findings and viral/proviral loads, according to a prospective study: symptomatic progressive (GI); asymptomatic progressive (GII); regressive (GIII); unclassified (GIV); or healthy (GV). |Correlations between these five groups and viral/proviral loads were evaluated. High viral and proviral loads were detected in GI and GII and viral loads were significantly associated with laboratory signs. Proviral loads detected in BM were significantly lower in GIII and GIV. GI cats were more likely to develop hematopoietic disorders than those from the other groups. Hematological and clinical disorders and disease severity are related to higher viral blood and proviral BM loads.

进行这项研究的目的是将自然感染猫白血病病毒的猫的临床，实验室和骨髓（BM）变化与其与血液和BM中的病毒载量以及BM中的前病毒载量相关联。根据一项前瞻性研究，根据抗原血症，临床和/或实验室检查结果以及病毒/实验量将猫分为五类。无症状进行性疾病（GII）；回归（GIII）；未分类（GIV）；或健康（GV）。|评估了这五个组与病毒/实验量之间的相关性。在GI和GII中检测到较高的病毒和前病毒载量，并且病毒载量与实验室体征显着相关。在GIII和GIV中，BM中检测到的前病毒负荷显着降低。与其他猫相比，胃肠道猫更容易发生造血系统疾病。血液学和临床疾病以及疾病的严重程度与病毒血液和原病毒BM负荷增加有关。