This study was conducted to correlate clinical, laboratory, and bone marrow (BM) changes in cats naturally infected with feline leukemia virus and their association with viral loads in blood and BM and proviral loads in BM. Cats were classified into five groups based on antigenemia, clinical and/or laboratory findings and viral/proviral loads, according to a prospective study: symptomatic progressive (GI); asymptomatic progressive (GII); regressive (GIII); unclassified (GIV); or healthy (GV). |Correlations between these five groups and viral/proviral loads were evaluated. High viral and proviral loads were detected in GI and GII and viral loads were significantly associated with laboratory signs. Proviral loads detected in BM were significantly lower in GIII and GIV. GI cats were more likely to develop hematopoietic disorders than those from the other groups. Hematological and clinical disorders and disease severity are related to higher viral blood and proviral BM loads.

本研究旨在将自然感染猫白血病病毒的猫的临床、实验室和骨髓 (BM) 变化及其与血液和 BM 中的病毒载量以及 BM 中的前病毒载量相关联。根据一项前瞻性研究，根据抗原血症、临床和/或实验室检查结果以及病毒/原病毒载量，将猫分为五组：症状进行性（GI）；无症状进行性（GII）；回归（GIII）；未分类（GIV）；或健康（GV）。 |评估了这五组与病毒/原病毒载量之间的相关性。在胃肠道和胃肠道中检测到高病毒和原病毒载量，并且病毒载量与实验室症状显着相关。 BM 中检测到的前病毒载量在 GIII 和 GIV 中显着较低。胃肠道猫比其他群体的猫更容易出现造血系统疾病。血液学和临床疾病以及疾病严重程度与较高的病毒血液和前病毒 BM 载量有关。