Plant natural products have broad applications in the pharmaceutical, food, cosmetics and flavor industries. However, the current manufacturing methods for plant natural products mainly rely on plant extraction and chemical synthesis, which are associated with unsustainability and severe environmental problems. The advancement of genetic technology has facilitated the engineering of microbes for producing plant natural products, but their industrial production titers remain low. Yarrowia lipolytica, a nonconventional yeast, is a promising and superior host for plant natural products manufacture, due to its advanced properties compared to conventional hosts. In this review, metabolic engineering approaches recently employed for overproduction of useful plant natural products, including terpenoids and polyketides, in Y. lipolytica are summarized. The current challenges for the biosynthesis of typical compounds are discussed and promising engineering strategies for future work are also suggested. This review provides guidance for engineering Y. lipolytica as a robust host for plant natural products production.

植物天然产物在制药，食品，化妆品和调味品行业具有广泛的应用。然而，当前用于植物天然产物的制造方法主要依赖于植物提取和化学合成，这与不可持续性和严重的环境问题有关。基因技术的进步促进了用于生产植物天然产物的微生物的工程改造，但是其工业生产效价仍然很低。解脂耶氏酵母非常规酵母，由于其与常规宿主相比的先进特性，是用于植物天然产物制造的有前途且优异的宿主。在这篇综述中，总结了近来用于在解脂耶氏酵母中过量生产有用的植物天然产物（包括萜类和聚酮化合物）的代谢工程方法。讨论了典型化合物生物合成的当前挑战，并提出了未来工作的有希望的工程策略。这篇综述为工程解脂耶氏酵母作为植物天然产物生产的强大宿主提供了指导。