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Green Reconstruction of MIL-100 (Fe) in Water for High Crystallinity and Enhanced Guest Encapsulation
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-05-14 , DOI: 10.1021/acssuschemeng.0c01471 Barbara E. Souza 1 , Annika F. Möslein 1 , Kirill Titov 1 , James D. Taylor 2 , Svemir Rudić 2 , Jin-Chong Tan 1
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-05-14 , DOI: 10.1021/acssuschemeng.0c01471 Barbara E. Souza 1 , Annika F. Möslein 1 , Kirill Titov 1 , James D. Taylor 2 , Svemir Rudić 2 , Jin-Chong Tan 1
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MIL-100 (Fe) is a highly porous metal–organic framework (MOF), considered as a promising carrier for drug delivery and for gas separation and capture applications. However, this functional material suffers from toxic synthesis that may hinder its biomedical use and large-scale production for commercial applications. Herein, we report a “green” mechanochemical water immersion approach to yield highly crystalline MIL-100 (Fe) material. Subsequently, we have harnessed this strategy for facile fabrication of drug@MOF composite systems, comprising (guests) 5-fluorouracil, caffeine, or aspirin encapsulated in the pores of (host) MIL-100 (Fe). Inelastic neutron scattering was uniquely used to probe the guest–host interactions arising from pore confinement of the drug molecules, giving additional insights into the reconstruction mechanism. Our results pave the way for “green” production of MIL-type materials and bespoke guest-encapsulated composites by minimizing the use of toxic chemicals, while enhancing energy efficiency and the material’s life cycle that is central to biotechnological applications.
中文翻译：
水中MIL-100（Fe）的绿色重构，可实现高结晶度和增强的客户封装
MIL-100（Fe）是一种高度多孔的金属有机框架（MOF），被认为是用于药物输送以及气体分离和捕获应用的有希望的载体。然而，这种功能材料遭受有毒的合成，这可能会阻碍其生物医学用途和商业应用的大规模生产。本文中，我们报告了一种“绿色”机械化学水浸法，可生产出高度结晶的MIL-100（Fe）材料。随后，我们利用此策略轻松制造了@MOF药物复合系统，该系统包含（客体）5-氟尿嘧啶，咖啡因或阿司匹林，其包裹在（宿主）MIL-100（Fe）的孔中。非弹性中子散射被独特地用来探测由药物分子的孔隙限制引起的客体-主体相互作用，从而为重建机理提供了更多见识。
更新日期：2020-05-14
中文翻译：
水中MIL-100（Fe）的绿色重构，可实现高结晶度和增强的客户封装
MIL-100（Fe）是一种高度多孔的金属有机框架（MOF），被认为是用于药物输送以及气体分离和捕获应用的有希望的载体。然而，这种功能材料遭受有毒的合成，这可能会阻碍其生物医学用途和商业应用的大规模生产。本文中，我们报告了一种“绿色”机械化学水浸法，可生产出高度结晶的MIL-100（Fe）材料。随后，我们利用此策略轻松制造了@MOF药物复合系统，该系统包含（客体）5-氟尿嘧啶，咖啡因或阿司匹林，其包裹在（宿主）MIL-100（Fe）的孔中。非弹性中子散射被独特地用来探测由药物分子的孔隙限制引起的客体-主体相互作用，从而为重建机理提供了更多见识。
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