Abstract

The development of mature biofilms is an aid in numerous aspects of the life cycle of fungi. It is well known that Sporothrix schenckii complex causes a benign subcutaneous mycosis, but recent studies have suggestedthat biofilm formation may be one of the important factors involved in its virulence. Here we report the study of the biomass organization and a model of the stages of S. schenckii biofilm development: adsorption, active adhesion, microcolony formation, maturation, and dispersal of biofilm fragments. During the development, the biofilm is surrounded by extracellular matrix, which contains glycoprotein (mannose rich), carbohydrates, lipids, and nucleic acid. In addition, the extracellular DNA increases in extracellular matrix as a key component to structural integrity and antifungal resistance. The study of S. schenckii biofilm contributes to a better understanding of growth biofilm and physiology, adding new insights into the mechanisms of virulence and persistence of pathogenic microorganisms.

中文翻译：

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Sporothrix schenckii的生物膜形成分析。

摘要

成熟生物膜的发展有助于真菌生命周期的许多方面。众所周知，Sporothrix schenckii复合物会引起良性皮下真菌病，但最近的研究表明生物膜的形成可能是其致病性的重要因素之一。在这里，我们报告的生物量组织和S.schenckii阶段模型的研究生物膜的发展：生物膜碎片的吸附，活性粘附，微菌落形成，成熟和分散。在发育过程中，生物膜被细胞外基质包围，其中含有糖蛋白（富含甘露糖），碳水化合物，脂质和核酸。另外，细胞外DNA在细胞外基质中增加，这是结构完整性和抗真菌抗性的关键成分。S. schenckii生物膜的研究有助于更好地了解生长生物膜和生理学，为病原微生物的毒力和持久性机制增添了新见解。