Diversity studies of endophytic assemblages are emerging challenges, which unveils novel phenotypes producing interesting chemical entities and a better understanding of their ecological significance. In the present investigation, we selected an extremely complex and unique environment supporting unexplored endophytes, 'Macroalgae of Kerala Coast, India'. Unlike terrestrial flora and mangroves, reports displaying endophytic assemblages of marine flora remain limited, especially from India. The main goal of this study was to expose hidden endophytic fungi from macroalgae and examination of their bioactive potential. An ecological investigation of four red, four green, and three brown algae resulted in 133 fungal taxa with 29 distinct morphospecies. Aspergillus and Penicillium were found to be the dominant genera. Penicillium chrysogenum was the sole fungi contributed 11% of the entire endophytic community. Antimicrobial activity against various aquaculture/human pathogens revealed that around 59% of endophytes inhibited at least one of the pathogens screened. The Maximum number of isolates (37%) inhibited E. coli tailed by A. fumigatus (27%). Antimicrobial profile of fungal endophytes endorses them as a potential source of bioactive molecules that can be explored to find a solution for drug resistance in microbial pathogens.

中文翻译：

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具有潜在药物先导的海洋大型藻类隐藏内生真菌的探索和分析。


内生组合的多样性研究正在面临新的挑战，它揭示了产生有趣化学实体的新表型，并更好地理解它们的生态意义。在本次调查中，我们选择了一个极其复杂且独特的环境，该环境支持未开发的内生菌，“印度喀拉拉邦海岸的巨藻”。与陆地植物群和红树林不同，显示海洋植物群内生组合的报道仍然有限，尤其是来自印度的报道。这项研究的主要目标是暴露大型藻类中隐藏的内生真菌并检查其生物活性潜力。对四种红藻、四种绿藻和三种褐藻的生态调查产生了 133 个真菌类群，具有 29 个不同形态种。发现曲霉属和青霉属是优势属。 Penicillium chrysogenum 是唯一的真菌，占整个内生群落的 11%。针对各种水产养殖/人类病原体的抗菌活性表明，约 59% 的内生菌至少抑制一种筛选的病原体。最大数量的分离株 (37%) 抑制了烟曲霉 (27%) 尾随的大肠杆菌。真菌内生菌的抗菌谱表明它们是生物活性分子的潜在来源，可以探索生物活性分子以找到微生物病原体耐药性的解决方案。