Dinuclear Cu₂(II,II)-cores stabilized by the N₃O donorset of HL¹ = (2-{[[di(2-pyridyl)methyl](methyl)amino]methyl}phenol), HL² = 2-({[di(2-pyridyl)methyl]amino}methyl)phenol), and HL³ = 2-({[di(2-pyridyl)methyl]amino}methyl)-4-nitrophenol display a unique superoxide dismutase (SOD) combined with catalase (CAT)-like activity in water, at neutral pH. The Cu₂L¹₂ < Cu₂L²₂ < Cu₂L³₂ structure–reactivity trend puts a spotlight on the electron-deficient core of Cu₂L³₂ that exhibits the highest SOD (log k_cat(O₂^•–) = 7.55) and CAT-like (k_H2O2 = 0.66 M^–1 s^–1) performance. Time-lapse ESI-MS and EPR experiments indicate that a dimeric core is essential for oxygenic turnover upon H₂O₂ decomposition.

中文翻译：

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在双核Cu（II）核上中和活性氧的中性：通过配体设计调整水中的抗氧化剂歧管

通过HL ¹ =（2-{[[[[（二（2-吡啶基）甲基]（甲基）氨基]甲基}苯酚）的N ₃ O供体组稳定的双核Cu ₂（II，II）-核，HL ² = 2- （{[（二（2-吡啶基）甲基]氨基}甲基）苯酚）和HL ³ = 2-（{[（二（吡啶基甲基）甲基]氨基}甲基）-4-硝基苯酚显示独特的超氧化物歧化酶（SOD ）与中性pH下的过氧化氢酶（CAT）样活性结合。所述的Cu ₂大号¹ ₂ <铜₂大号² ₂ <铜₂大号³ ₂结构反应性趋势看跌聚光灯上的缺电子的芯的Cu₂ L ³ ₂表现出最高的SOD（log k _cat（O ₂ ^•–）= 7.55）和类CAT（ k _{H 2 O 2} = 0.66 M ^–1 s ^–1）。延时ESI-MS和EPR实验表明，二聚体核心对于H ₂ O ₂分解时的氧气转换至关重要。