ABSTRACT

Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokine produced early during blood-stage malaria infection that has an unknown physiological role during malaria infection. We demonstrate that B cell-intrinsic IFNλ signals suppress the acute antibody response, acute plasmablast response, and impede acute parasite clearance during a primary blood-stage malaria infection. Our findings demonstrate a previously unappreciated role for B cell intrinsic IFNλ-signaling in the initiation of the humoral immune response in the host response to experimental malaria.

摘要

抗体在宿主对血液阶段疟疾感染的反应中起着至关重要的保护作用。目前尚不清楚细胞因子在塑造对血液疟疾的抗体应答中的作用。λ干扰素（IFNλ）是一种III型干扰素，是血液阶段疟疾感染早期产生的一种细胞因子，在疟疾感染期间具有未知的生理作用。我们证明B细胞本征IFNλ信号抑制急性抗体反应，急性浆母细胞反应，并在主要的血液阶段疟疾感染过程中阻止急性寄生虫清除。我们的发现表明，在宿主对实验性疟疾的反应中，体液免疫反应的启动中，B细胞内在干扰素λ信号的作用此前未被认识到。