Research question

Does anogenital distance (AGD) differ in newborn infants conceived through assisted reproduction technology (ART) compared with those conceived naturally?

Design

This case–control study looked at anthropometric and anogenital measurements in 247 male and 200 female newborns born after ART (n = 121) or natural conception (n = 326), within 24 h of birth. Anogenital measurements included distance from the centre of the anus to the anterior clitoris (AGDAC) and to the posterior fourchette (AGDAF) in female infants, and from the centre of the anus to the posterior base of the scrotum (AGDAS) and to the anterior base of the penis (AGDAP) in male infants.

Results

ART mothers were older, more likely to be nulliparous and delivered by Caesarean section at an earlier gestational week. AGDAS of male infants was approximately twice the AGDAF of female infants (17.6 ± 5.0 versus 9.1 ± 3.6 mm). AGDAF in female infants conceived by ART compared with those conceived naturally was not significantly different (8.8 ± 3.6 versus 9.3 ± 3.6 mm; P = 0.404). AGDAC were also comparable for both groups (27.4 ± 6.3 versus 27.7 ± 7.1 mm; P = 0.770). In male infants, no significant difference was seen between ART and natural conception groups in terms of AGDAS (17.4 ± 4.6 versus 17.7 ± 5.2 mm, P = 0.742) and AGDAP (37.5 ± 6.6 versus 38.0 ± 6.7 mm, P = 0.589). When adjusted for gestational age, weight, length and head circumference, mode of conception was not associated with differences in any of the anogenital measurements.

Conclusions

AGD measurements in infants conceived by ART are no different from those of infants conceived naturally.

中文翻译：

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通过辅助生殖和自然受孕受孕的新生儿的肛门生殖器距离。

研究问题

与自然受孕的婴儿相比，通过辅助生殖技术 (ART) 受孕的新生儿的肛门生殖器距离 (AGD) 是否不同？

设计

本病例对照研究研究了 247 名男性和 200 名女性新生儿在 ART ( n  = 121) 或自然受孕 ( n  = 326) 后出生 24 小时内的人体测量和肛门生殖器测量值。肛门生殖器测量包括从肛门中心到阴蒂前部 (AGDAC) 和女婴后宫 (AGDAF) 的距离，以及从肛门中心到阴囊后基部 (AGDAS) 和前部的距离。男婴的阴茎根部 (AGDAP)。

结果

ART 母亲年龄较大，更有可能未生育并在较早的妊娠周通过剖腹产分娩。男婴的 AGDAS 大约是女婴的 AGDAF 的两倍（17.6 ± 5.0 对 9.1 ± 3.6 毫米）。与自然受孕的女婴相比，通过 ART 受孕的女婴的 AGDAF 没有显着差异（8.8 ± 3.6 对 9.3 ± 3.6 毫米；P  = 0.404）。两组的 AGDAC 也具有可比性（27.4 ± 6.3 对 27.7 ± 7.1 mm；P  = 0.770）。在男婴中，ART 组和自然受孕组在 AGDAS（17.4 ± 4.6 对 17.7 ± 5.2 毫米，P  = 0.742）和 AGDAP（37.5 ± 6.6 对 38.0 ± 6.7 毫米，P = 0.589）。当根据胎龄、体重、身长和头围进行调整后，受孕方式与任何肛门生殖器测量值的差异无关。

结论

ART 受孕婴儿的 AGD 测量值与自然受孕婴儿的 AGD 测量值没有区别。