HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles,Green Chemistry

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HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles
Green Chemistry ( IF 9.3 ) Pub Date : 2020-05-14 , DOI: 10.1039/d0gc00757a
Sagar R Mudshinge ₁ , Chinmay S Potnis ₁ , Bo Xu ₂ , Gerald B Hammond ₁

Affiliation

We report an efficient HCl·DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl·DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability.

中文翻译：

HCl·DMPU辅助的一锅无醛醛转化为腈

我们报告了一种有效的HCl·DMPU辅助将一锅法将醛转化为腈的方法。将HCl·DMPU用作酸性来源和非亲核碱均构成制备腈的环境温和的替代方法。我们的操作规程顺利进行，无需使用有毒的试剂和金属催化剂。结合了各种官能团的各种官能化的芳香族，脂肪族和烯丙基醛已成功地以优异的定量转化为腈。该协议的特点是底物范围广，反应条件温和，可扩展性高。

更新日期：2020-07-06

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