Abstract

Two series of sulfonate derivatives of carvacrol and thymol were synthesized and screened in vitro for their anti-oomycete activity against Phytophthora capsici, respectively. Among all of 32 derivatives, five compounds 3a, 4a, 4k, 3n, and 4n exhibited more potent anti-oomycete activity against P. capsici with EC₅₀ values of 66.66, 62.94, 68.65, 61.24, and 52.91 mg/L, respectively. This suggested that introduction of different substitutions at the hydroxyl position of 1/2 could have remarkable effect on anti-oomycete activity. Overall, when R¹ = isopropyl and R² = methyl, the anti-oomycete activities of the compounds were higher than that of the corresponding compounds of R¹ = methyl and R² = isopropyl.

摘要

合成了香芹酚和百里酚的两个系列磺酸盐衍生物，并分别在体外筛选了它们对辣椒疫霉的抗卵菌活性。在所有32个衍生物，五种化合物的图3a，图4a，4K，3N，和4N针对表现出更有效的抗卵菌纲活性辣椒疫霉用EC ₅₀的66.66，62.94，68.65，61.24，52.91和毫克/升，分别值。这表明在1 / 2的羟基位置引入不同的取代可以对抗卵菌活性产生显着影响。总的来说，当 R¹ = 异丙基，R ² = 甲基，化合物的抗卵菌活性高于对应的R ¹ = 甲基和R ² = 异丙基化合物。