ABSTRACT

The increase in the occurrence of the pharmaceuticals in the environmental compartments is becoming emerging concern as it reflects their inefficient treatment in the wastewater treatment plants which are the main sources of these micropollutants. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and frequently detected pain medications in wastewater treatment plants. A lab scale sequencing batch reactor (SBR) was operated for seven months and acute inhibitory effect of NSAIDs on activated sludge was tested with respirometry. Culture amendment with different concentrations of NSAIDs in the presence as well as absence of nitrification inhibitor resulted in considerable variation in the oxygen uptake rate (OUR) profiles. The decrease in OUR and nitrate production rate governed with reduced heterotrophic and nitrification activity. The kinetics of half saturation for growth and maximum autotrophic growth rates are determined to be affected negatively by the acute impact of anti-inflammatory pharmaceuticals even at the environmentally relevant concentrations. High removal of tested NSAIDs was observed even for the first time introduce with these compounds.

摘要

环境隔间中药物出现的增加正成为新出现的问题，因为这反映了它们在废水处理厂中的低效处理，而废水处理厂是这些微污染物的主要来源。非甾体抗炎药 (NSAID) 是废水处理厂中最常用和最常检测到的止痛药之一。实验室规模的序批式反应器 (SBR) 运行了七个月，并通过呼吸测定法测试了 NSAIDs 对活性污泥的急性抑制作用。在存在和不存在硝化抑制剂的情况下，用不同浓度的 NSAID 进行培养修正导致氧摄取率 (OUR) 曲线的相当大的变化。OUR 和硝酸盐生成率的降低与异养和硝化活性的降低有关。即使在环境相关浓度下，半饱和生长动力学和最大自养生长速率也受到抗炎药物的急性影响的负面影响。即使是首次引入这些化合物，也观察到测试的 NSAID 的去除率很高。