Introduction: In the current study, we are going to look at different factors responsible for the diagnostic delay of ALS patients among the sample of Egyptian patients. Method/patients: This is a cohort study. ALS patients were recruited from December 2018 to January 2020 from the ALS clinic at the international medical center (IMC) (Cairo, Egypt). We analyzed the site of onset, the time from symptom onset to diagnosis, age and sex differences among these ALS patients. Results: Thirty patients were included in the study. Seventy percent of the patients had limb onset ALS with a mean age of onset of 50 ± 12.1 vs 58.6 ± 2.1 years for the patients with bulbar onset (p = 0.02). Bulbar-onset patients were diagnosed earlier than limb onset patients (mean lag of 8.2 ± 2.57 months vs 22.95 ± 17.6 months respectively, p < 0.05). The average diagnosis time for women was slightly longer than that of men with a mean lag of 20.7 ± 21.1 vs. 17.6 ± 13.6 months, respectively, p > 0.05. Diagnostic delay and age at onset of symptoms were negatively correlated, however, this was not statistically significant. Discussion: To our knowledge, this the first population-based study from Egypt about predicting factors of diagnostic delay among Egyptian patients. Limb onset, female gender and young age are correlated with increased mean time to diagnosis. Statistically insignificant results could be attributed to a small sample. Larger population-based studies are needed from Egypt.

介绍：在当前的研究中，我们将在埃及患者样本中研究导致 ALS 患者诊断延迟的不同因素。方法/患者：这是一项队列研究。ALS 患者是从 2018 年 12 月至 2020 年 1 月从国际医疗中心 (IMC)（埃及开罗）的 ALS 诊所招募的。我们分析了这些 ALS 患者的发病部位、从症状出现到诊断的时间、年龄和性别差异。结果： 研究中包括了 30 名患者。70% 的患者患有肢体 ALS，平均发病年龄为 50 ± 12.1 岁，而延髓发病患者的平均发病年龄为 58.6 ± 2.1 岁（p = 0.02）。延髓发病患者的诊断时间早于肢体发病患者（平均滞后分别为 8.2 ± 2.57 个月和 22.95 ± 17.6 个月，p  < 0.05）。女性的平均诊断时间略长于男性，平均滞后时间分别为 20.7 ± 21.1 和 17.6 ± 13.6 个月，p  > 0.05。诊断延迟和症状出现时的年龄呈负相关，然而，这在统计学上并不显着。讨论：据我们所知，这是埃及第一项关于预测埃及患者诊断延迟因素的基于人群的研究。肢体发病、女性和年轻与平均诊断时间增加相关。统计上不显着的结果可归因于小样本。埃及需要进行更大规模的基于人群的研究。