Leptin potentially exerts atherogenic effects.This study evaluated the relationship between serum leptin levels and aortic stiffness in patients with stage 3-5 chronic kidney disease (CKD). Totally 205 participants were enrolled. Fasting blood sample were checked and serum leptin were measured by enzyme immunoassay. Aortic stiffness was measured as the carotid-femoral pulse wave velocity (cfPWV). 73 (35.6%) of 205 patients showed cfPWV >10 m/s were defined as aortic stiffness group. Compared with the remaining patients, the aortic stiffness group had high prevalence of diabetes mellitus, older age, higher waist circumference, body fat mass, systolic blood pressure, fasting glucose, and higher serum leptin level. In multivariable logistic regression analysis the independent predictors of cfPWV >10 m/s included leptin levels (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.027-1.095, P < 0.001), age (OR: 1.064, 95% CI: 1.033-1.096, P< 0.001), and systolic blood pressure (OR: 1.021, 95% CI: 1.006-1.037, P = 0.006). Multivariable forward stepwise linear regression analysisshowed a positive association between log-transformed leptin levels and log-cfPWV (β = 0.192, adjusted R2 change = 0.042, P = 0.001). Thus, aortic stiffness is positively correlated with serum leptin levels in patients with stage 3-5 CKD.Abbreviations: BUN, blood urea nitrogen; cfPWV, carotid-femoral pulse wave velocity; CI, confidence interval; CKD, chronic kidney disease; Cre, creatinine; DBP, diastolic blood pressure; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio; SBP, systolic blood pressure; TCH, total cholesterol; TG, triglycerides.

中文翻译：

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患有慢性肾脏疾病3-5期的患者的血清瘦素水平与主动脉僵硬程度呈正相关。

瘦素可能发挥动脉粥样硬化作用。这项研究评估了3-5岁慢性肾脏病（CKD）患者血清瘦素水平与主动脉僵硬度之间的关系。共有205名参与者参加。检查空腹血样并通过酶免疫测定法测定血清瘦素。测量主动脉僵硬度，作为颈股脉搏波速度（cfPWV）。205例患者中有73例（35.6％）显示cfPWV> 10 m / s被定义为主动脉僵硬组。与其余患者相比，主动脉僵硬组的糖尿病患病率高，年龄大，腰围高，体脂量，收缩压，空腹血糖和血清瘦素水平高。在多变量logistic回归分析中，cfPWV> 10 m / s的独立预测因子包括瘦素水平（几率[OR]：1.061，95％置信区间[CI]：1.027-1.095，P <0.001），年龄（OR：1.064，95％CI：1.033-1.096，P <0.001），收缩压（OR：1.021，95％CI ：1.006-1.037，P ＝ 0.006）。多变量正向逐步线性回归分析显示对数转化的瘦素水平与log-cfPWV之间呈正相关（β= 0.192，调整后的R2变化= 0.042，P = 0.001）。因此，3-5级CKD患者的主动脉僵硬度与血清瘦素水平呈正相关。cfPWV，颈股脉搏波速度；CI，置信区间；CKD，慢性肾脏疾病；Cre，肌酐；DBP，舒张压；DM，糖尿病；eGFR，估计的肾小球滤过率；LDL-C，低密度脂蛋白胆固醇；或，优势比；SBP，收缩压；TCH，总胆固醇；TG