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Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies.
Brain Sciences ( IF 2.7 ) Pub Date : 2020-05-14 , DOI: 10.3390/brainsci10050292
Ike C de la Peña 1 , Michael C Pan 2, 3 , Chau Giang Thai 1 , Tamara Alisso 1
Affiliation  

Research on the predominantly inattentive attention-deficit/hyperactivity disorder (ADHD-PI) subtype/presentation is important given its high prevalence, but paradoxically it is under-recognized and undertreated. The temporal stability of the inattention symptom could impact the high worldwide prevalence of ADHD-PI. Some evidence suggests differences in the nature of attentional deficit in ADHD-PI vs. that in other subtypes. Impairments in neuropsychological, neurocognitive, and social functioning are also evident in ADHD-PI, which could be specific to the subtype (e.g., processing speed, social perception, and skills), or differ from others in severity. Neuroimaging studies have also revealed ADHD-PI-specific neuropathological abnormalities and those that are shared with other subtypes. ADHD-PI is highly comorbid with learning and internalizing (e.g., anxiety and depression) disorders. There is no solid evidence for ADHD-PI-specific genetic etiologies and differential responses of subtypes to ADHD medications. Translational studies have used the Wistar Kyoto/NCrl substrain which requires further characterizations as an ADHD-PI model. Overall, ADHD-PI research has been conducted in the context of the Diagnostic and Statistical Manual, which arguably does not conform to the widely recognized "dimensional" view of ADHD. The Research Domain Criteria has been proposed to provide a novel framework for understanding the nature of neuropsychiatric illnesses and ultimately improve their diagnosis and treatment.

中文翻译:

注意缺陷/多动障碍主要是注意力不集中的亚型/表现:研究进展和转化研究。

考虑到注意力不集中/多动症(ADHD-PI)的高患病率,对它的研究很重要,但自相矛盾的是,人们对其认识和治疗不足。注意力不集中症状的时间稳定性可能会影响ADHD-PI在全球的高患病率。一些证据表明,ADHD-PI与其他亚型的注意缺陷性质不同。在ADHD-PI中神经心理,神经认知和社会功能的损害也很明显,这可能是亚型所特有的(例如,处理速度,社会认知和技能),或在严重性上与其他人不同。神经影像学研究还揭示了ADHD-PI特有的神经病理学异常以及与其他亚型共有的异常。ADHD-PI与学习和内在化(例如焦虑和抑郁)疾病高度共存。没有确凿的证据表明ADHD-PI特异的遗传病因和亚型对ADHD药物的不同反应。转换研究已使用Wistar Kyoto / NCrl子菌株,该菌株需要进一步表征为ADHD-PI模型。总体而言,ADHD-PI研究是在《诊断和统计手册》的背景下进行的,它可能不符合公认的ADHD的“维度”观点。已经提出了“研究领域标准”,以提供一个新颖的框架来理解神经精神疾病的本质,并最终改善其诊断和治疗。没有确凿的证据表明ADHD-PI特异的遗传病因和亚型对ADHD药物的不同反应。转换研究已使用Wistar Kyoto / NCrl子菌株,该菌株需要进一步表征为ADHD-PI模型。总体而言,ADHD-PI研究是在《诊断和统计手册》的背景下进行的,它可能不符合公认的ADHD的“维度”观点。已经提出了“研究领域标准”,为理解神经精神疾病的性质并最终改善其诊断和治疗提供了一个新颖的框架。没有确凿的证据表明ADHD-PI特异的遗传病因和亚型对ADHD药物的不同反应。转换研究已使用Wistar Kyoto / NCrl子菌株,该菌株需要进一步表征为ADHD-PI模型。总体而言,ADHD-PI研究是在《诊断和统计手册》的背景下进行的,它可能不符合公认的ADHD的“维度”观点。已经提出了“研究领域标准”,为理解神经精神疾病的性质并最终改善其诊断和治疗提供了一个新颖的框架。ADHD-PI研究是在《诊断和统计手册》的背景下进行的,该手册可能不符合公认的ADHD的“维度”观点。已经提出了“研究领域标准”,以提供一个新颖的框架来理解神经精神疾病的本质,并最终改善其诊断和治疗。ADHD-PI研究是在《诊断和统计手册》的背景下进行的,该手册可能不符合公认的ADHD的“维度”观点。已经提出了“研究领域标准”,以提供一个新颖的框架来理解神经精神疾病的本质,并最终改善其诊断和治疗。
更新日期:2020-05-14
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