New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 μg/mL.

中文翻译：

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Mersaquinone，一种来自海洋衍生链霉菌属的新四环衍生物。EG1对耐甲氧西林金黄色葡萄球菌（MRSA）的活性。

迫切需要新的抗生素来克服耐甲氧西林的金黄色葡萄球菌（MRSA）所面临的社会挑战。在这项研究中，一种新的并四苯衍生物名为Mersaquinone（1），以及已知的Tetracenomycin D（2），Resistoflavin（3）和Resistomycin（4）已从海洋链霉菌sp。的有机提取物中分离得到。EG1。该菌株是从埃及地中海北海岸收集的沉积物样品中分离出来的。基于多种光谱技术的数据（包括HRESIMS，IR，1D和2D NMR测量）确定了巯基醌（1）的化学结构。Mersaquinone（1）对耐甲氧西林的金黄色葡萄球菌表现出抗菌活性，最低抑菌浓度为3.36μg/ mL。