当前位置: X-MOL 学术Antibiotics › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).
Antibiotics ( IF 4.3 ) Pub Date : 2020-05-14 , DOI: 10.3390/antibiotics9050252
Min Cheol Kim 1 , Reiko Cullum 1 , Ali M S Hebishy 2 , Hala A Mohamed 2 , Ahmed H I Faraag 3 , Nehad M Salah 1 , Mohamed S Abdelfattah 2 , William Fenical 1
Affiliation  

New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 μg/mL.

中文翻译:

Mersaquinone,一种来自海洋衍生链霉菌属的新四环衍生物。EG1对耐甲氧西林金黄色葡萄球菌(MRSA)的活性。

迫切需要新的抗生素来克服耐甲氧西林的金黄色葡萄球菌(MRSA)所面临的社会挑战。在这项研究中,一种新的并四苯衍生物名为Mersaquinone(1),以及已知的Tetracenomycin D(2),Resistoflavin(3)和Resistomycin(4)已从海洋链霉菌sp。的有机提取物中分离得到。EG1。该菌株是从埃及地中海北海岸收集的沉积物样品中分离出来的。基于多种光谱技术的数据(包括HRESIMS,IR,1D和2D NMR测量)确定了巯基醌(1)的化学结构。Mersaquinone(1)对耐甲氧西林的金黄色葡萄球菌表现出抗菌活性,最低抑菌浓度为3.36μg/ mL。
更新日期:2020-05-14
down
wechat
bug