Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD), resulting in strictures and ultimately obstruction, which is a significant clinical problem. Fibrosis is mainly triggered by local chronic inflammation and occurs when excessive extracellular matrix deposition is caused by activated mesenchymal cells. Despite the advance of anti‐inflammatory therapies in IBD, the incidence and preventive strategies of intestinal fibrosis and strictures in IBD have not significantly changed over time. This shows that inflammation is necessary for fibrosis, but it does not necessarily affect the fibrotic progression. This review summarizes current knowledge about the non‐inflammatory mechanisms implicated in the gut fibrotic process of IBD, which may pave the way for new mechanisms and anti‐fibrotic therapies.

中文翻译：

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非炎性因子在肠纤维化中的作用。

肠纤维化是炎症性肠病（IBD）的常见并发症，导致狭窄和最终阻塞，这是一个重要的临床问题。纤维化主要由局部慢性炎症引起，并在活化的间充质细胞引起过多的细胞外基质沉积时发生。尽管IBD的抗炎治疗取得了进步，但IBD肠纤维化和狭窄的发生率和预防策略并未随时间发生显着变化。这表明炎症是纤维化所必需的，但不一定影响纤维化的进程。这篇综述总结了有关IBD肠纤维化过程中非炎性机制的最新知识，这可能为新的机制和抗纤维化疗法铺平道路。