Despite improvements in prevention and treatment, cervical cancer (CC) still poses a serious threat to women’s health. CHMP4C (chromatin modified protein 4C) is a subunit of the endosomal sorting complex required for transport, which is expressed in both nucleus and cytoplasm. Here, we examined the effect of CHMP4C on the biological behavior of CC cells and the underlying mechanisms. We report that CHMP4C expression is higher in CC tissues, and high CHMP4C expression is associated with lower survival. Up‐regulation of CHMP4C in C‐33A cells accelerates cell proliferation, migration and invasion, whereas down‐regulation of CHMP4C in Ca Ski cells had the opposite effect. Moreover, overexpression of CHMP4C induced activation of the epithelial–mesenchymal transition pathway, whereas depletion of CHMP4C inhibited activation. Our results suggest that CHMP4C contributes to the viability and motility of CC cells by modulating epithelial–mesenchymal transition and may facilitate the identification of novel biomarkers for CC therapy.

中文翻译：

---

染色质修饰蛋白4C（CHMP4C）促进宫颈癌细胞的恶性发展。

尽管在预防和治疗方面有所改进，但宫颈癌 (CC) 仍然对女性健康构成严重威胁。CHMP4C（染色质修饰蛋白 4C）是转运所需的内体分选复合物的一个亚基，在细胞核和细胞质中均有表达。在这里，我们检查了 CHMP4C 对 CC 细胞生物学行为的影响及其潜在机制。我们报告说，CC 组织中 CHMP4C 表达较高，并且 CHMP4C 高表达与较低的存活率相关。C-33A 细胞中 CHMP4C 的上调会加速细胞增殖、迁移和侵袭，而 Ca Ski 细胞中 CHMP4C 的下调则具有相反的效果。此外，CHMP4C 的过表达诱导上皮-间充质转化途径的激活，而 CHMP4C 的消耗抑制了激活。