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Temporal modulation of optical energy for enhanced photothermal hemostasis of intraoperative bleeding during laser treatment.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-05-25 , DOI: 10.1002/jbio.202000086 Suhyun Park 1 , Hyun Wook Kang 2
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-05-25 , DOI: 10.1002/jbio.202000086 Suhyun Park 1 , Hyun Wook Kang 2
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Intraoperative bleeding during laser treatment of benign prostate hyperplasia (BPH) often impedes cystoscopic vision, necessitating the use of conventional hemostatic devices. This study proposes an optical technique to improve the efficacy of photothermal hemostasis of bleeders during laser prostatectomy by temporally modulating a 532 nm laser beam. A perfused porcine kidney model is established to quantitatively investigate various optical pulse patterns and irradiation modes. Thermal simulations demonstrate a high success rate of complete hemostasis achieved by the modulated 532 nm pulse pattern. In comparison to the irradiation modes typically employed for hemostasis, the modulated 532 nm mode exhibits a short coagulation time and minimal thermal injury. ex vivo and in vivo cystoscopic observations validate the clinical feasibility of the proposed optical energy modulation method to regulate intraoperative bleeding.
中文翻译：
光能的时间调制可增强激光治疗过程中术中出血的光热止血效果。
激光治疗良性前列腺增生（BPH）期间的术中出血通常会妨碍膀胱镜检查的视力，因此必须使用常规的止血装置。这项研究提出了一种光学技术，可以通过临时调制532 nm激光束来提高激光前列腺切除术中出血的光热止血效果。建立了猪肾脏灌注模型，以定量研究各种光脉冲模式和照射模式。热模拟表明，通过调制的532 nm脉冲模式可实现完全止血的高成功率。与通常用于止血的照射模式相比，调制的532 nm模式显示出较短的凝结时间和最小的热损伤。
更新日期：2020-05-25
中文翻译：
光能的时间调制可增强激光治疗过程中术中出血的光热止血效果。
激光治疗良性前列腺增生（BPH）期间的术中出血通常会妨碍膀胱镜检查的视力，因此必须使用常规的止血装置。这项研究提出了一种光学技术，可以通过临时调制532 nm激光束来提高激光前列腺切除术中出血的光热止血效果。建立了猪肾脏灌注模型，以定量研究各种光脉冲模式和照射模式。热模拟表明，通过调制的532 nm脉冲模式可实现完全止血的高成功率。与通常用于止血的照射模式相比，调制的532 nm模式显示出较短的凝结时间和最小的热损伤。
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