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Visualization of penetration of topical antifungal drug substances through mycosis‐infected nails by matrix assisted laser desorption ionization mass spectrometry imaging
Mycoses ( IF 4.9 ) Pub Date : 2020-05-28 , DOI: 10.1111/myc.13103
Fernanda Endringer Pinto 1 , Charlotte Bagger 1 , Gernot Kunze 2 , Nicolas Joly-Tonetti 2 , Jean-Paul Thénot 3 , Hanan Osman-Ponchet 3 , Christian Janfelt 1
Affiliation  

Matrix‐assisted laser desorption ionisation mass spectrometry imaging (MALDI‐MSI) is a mass spectrometry‐based technique, which can be applied for compound‐specific imaging of pharmaceuticals in tissues samples. MALDI‐MSI technology is widely used to visualise penetration and distribution profile through different tissues but has never been used with nail tissue.

中文翻译:

通过基质辅助激光解吸电离质谱成像观察局部抗真菌药物穿透真菌感染的指甲

基质辅助激光解吸电离质谱成像 (MALDI-MSI) 是一种基于质谱的技术,可用于组织样品中药物的化合物特异性成像。MALDI-MSI 技术广泛用于可视化通过不同组织的渗透和分布轮廓,但从未用于指甲组织。
更新日期:2020-05-28
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