Spatially restricted expression of genes by global circulating inducers (hormones, secreted proteins, growth factors, neuromodulators, etc.) was a prerequisite for the evolution of animals. Far from a random occurrence, it is a systematically occurring, certain event, implying that specific information is invested for it to happen. In this minireview, we show for the first time that the expression and regionalization takes place at the level of receptors via a neural mechanism and make an attempt to reconstruct the causal chain from neural signaling to expression of nuclear receptors.

中文翻译：

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核受体表达和区域化的神经机制。

全球循环诱导剂（激素、分泌蛋白、生长因子、神经调节剂等）在空间上限制基因表达是动物进化的先决条件。它远非随机事件，而是系统性发生的特定事件，这意味着投入了特定信息以使其发生。在这篇小型综述中，我们首次表明表达和区域化通过神经机制在受体水平发生，并尝试重建从神经信号传导到核受体表达的因果链。