Semaphorin6A (Sema6A) and its PlexinA2 (PlxnA2) receptor canonically function as repulsive axon guidance cues. To understand downstream signaling mechanisms, we performed a microarray screen and identified the “clutch molecule” shootin‐1 (shtn‐1) as a transcriptionally repressed target. Shtn‐1 is a key proponent of cell migration and neuronal polarization and must be regulated during nervous system development. The mechanisms of Shtn‐1 regulation and the phenotypic consequences of loss of repression are poorly understood.

中文翻译：

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斑马鱼的神经系统发育需要Shootin-1。

Semaphorin6A (Sema6A) 和它的 PlexinA2 (PlxnA2) 受体典型地作为排斥性轴突引导线索起作用。为了了解下游信号传导机制，我们进行了微阵列筛选，并将“离合器分子” shootin-1 ( shtn-1) 鉴定为转录抑制目标。Shtn-1 是细胞迁移和神经元极化的关键支持者，必须在神经系统发育过程中受到调节。Shtn-1 调节的机制和抑制丧失的表型后果知之甚少。