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Antibacterial and Degradable Thioimidazolium Poly(ionic liquid)
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2020-05-13 , DOI: 10.1021/acssuschemeng.0c02666
Christene Anne Smith 1 , Vincenzo Alessandro Cataldo 1 , Thomas Dimke 2 , Ina Stephan 2 , Ryan Guterman 1
Affiliation  

New antibacterial agents are urgently required to fight the emergence of antibiotic-resistant bacteria. We recently synthesized the first thioimidazolium ionene, which has antibacterial properties and can degrade in various media. This dual functionality is crucial in order to limit the environmental impact of these biocides. We have found that our polymer is stronger than benzalkonium chloride (BAC) against Pseudomonas aeruginosa and also readily degrades in the presence of base, while remaining stable in acidic environments. These results highlight a new emerging class of antibacterial degradable polymers.

中文翻译:

抗菌可降解的硫咪唑鎓离子液体

迫切需要新的抗菌剂来对抗抗生素抗性细菌的出现。我们最近合成了第一个硫代咪唑鎓紫罗烯,它具有抗菌特性并且可以在各种介质中降解。为了限制这些杀菌剂对环境的影响,双重功能至关重要。我们发现我们的聚合物对铜绿假单胞菌的抵抗力比苯扎氯铵(BAC)强,并且在存在碱的情况下也易于降解,同时在酸性环境中保持稳定。这些结果突出了新兴的一类抗菌可降解聚合物。
更新日期:2020-05-13
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