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Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor
bioRxiv - Synthetic Biology Pub Date : 2020-05-13 , DOI: 10.1101/2020.05.11.089011
William B. Black , Derek Aspacio , Danielle Bever , Edward King , Linyue Zhang , Han Li

Background Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. However, these noncanonical redox cofactors need to be biologically synthesized to achieve full integration with renewable biomanufacturing processes.

中文翻译:

大肠杆菌的代谢工程,可优化烟酰胺单核苷酸(一种非规范的氧化还原辅助因子)的生物合成

背景技术非规范氧化还原辅助因子正在成为无细胞生物合成中的重要工具,以增加经济可行性,实现精细控制并扩大可获得的化学物质的范围。但是,这些非规范氧化还原辅助因子需要进行生物合成,以实现与可再生生物制造工艺的完全整合。
更新日期:2020-05-13
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