Abstract

A new secoiridoid glycoside, 3’-O-p-trans-coumaroylsweroside (1), together with twenty-nine compounds (2–30), were isolated from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Their structures were identified by analysis of mass spectrometric and NMR spectroscopic data. Compounds 2, 4, 6, 11 and 13–15 showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines (KKU-213, KKU-055 and KKU-214). We report the first phytochemical investigation of the roots and flowers of F. fragrans, as only the essential oil of the latter has been investigated.

中文翻译：

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来自 Fagraea fragrans Roxb 的根和花的一种新的半环萜苷和其他成分。(龙胆科)

摘要

一种新的糖苷secoiridoid，3'- ö - p -反式-coumaroylsweroside（1），加上29化合物（2 - 30），从根和花中分离灰莉属香的罗。（龙胆科）。它们的结构是通过分析质谱和核磁共振光谱数据确定的。化合物2，4，6，11和13 - 15对胆管癌细胞系（KKU-213、KKU-055 和 KKU-214）显示出弱至中度的细胞毒性。我们报告了F. fragrans根和花的第一次植物化学研究，因为只研究了后者的精油。